What Are the Risk Factors for Abdominal Pain Disorders of Gut-Brain Interaction?
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What Are the Risk Factors for Abdominal Pain Disorders of Gut-Brain Interaction?

Vanessa M. Shami, MD, FASGE, reviewing Zia JK, et al. Gastroenterology 2022 Jun 15.

Abdominal pain-related disorders of gut-brain interaction (AP-DGBI) affect a sizable portion of the population. Irritable bowel syndrome (IBS) is one of the most common forms of AP-DGBI. Identifying risk and protective factors is the first step in better understanding and managing the disease. This systematic review aimed to determine clinical risk and protective factors for the presence and persistence of AP-DGBI in children and adults.

The review included 348 studies. Only fully published studies with a control group were included, and studies deemed poor quality (using a validated scale) were excluded. Whenever possible, a meta-analysis generated pooled odds ratios or mean difference. 

Risk factors for the development of AP-DGBI in adults and children included female sex, gastroenteritis, abuse, stress, psychological disorders, somatic symptoms, and poor sleep. In adults, additional risk factors included obesity, smoking, and increased use of medical resources, whereas protective factors included social support and optimism. No studies on protective factors for children were found.

Vanessa M. Shami, MD, FASGE

COMMENT

AP-DGBI is a major source of morbidity. Identifying the risk and protective factors helps us understand and potentially manage the disease. There is a paucity of literature on protective factors for AP-DGBI in children, which suggests that research in this area is needed.

Note to readers: At the time we reviewed this paper, its publisher noted that it was not in final form and that subsequent changes might be made.

CITATION(S)

Zia JK, Lenhart A, Yang PL, et al. Risk factors for abdominal pain disorders of gut brain interaction in adults and children: a systematic review. Gastroenterology 2022 Jun 15. (Epub ahead of print) (https://doi.org/10.1053/j.gastro.2022.06.028)

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